Clarify Clinics

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Protocols

Clarify Protocols

Clarify has different protocols based on each Clari by Marker procedure. Please discuss your desired treatment with your health care professional.

Detoxification Treatment

For patients looking to detoxify their bodies of man-made chemical and toxins to live a longer, healthier life.

Rationale:

Poisons, toxins and man-made chemicals accumulate in our bodies every day from what we eat, drink and breathe. Our bodies are unable to effectively remove the PFASs, BPAs, dioxins, herbicides, pesticides and microplastics. Microplastics are in our food11, our air (particularly in urban settings)12, and our clothing13. PFASs are similarly ubiquitous14–16. Microplastics have been found in brains, testes, and carotid artery plaques 8,17,18.

These chemicals are associated with poor health, and likely contribute to diseases including altered immune and thyroid function, liver disease, lipid and insulin dysregulation, kidney disease, adverse reproductive and developmental outcomes, and cancer19–21. Patients whose arterial plaques contain microplastics have a higher risk of death18.

Prior to the Marker Treatment, there has been no effective way to rid ourselves of any of these microplastics and chemicals in our blood.

Treatment regime:

1-3 treatments per year. Our proposed protocol is based on our bench testing, in which we remove 35-99% of these chemicals in your blood per treatment.

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Detoxification protocol

WHO

Patients looking to detoxify their bodies of manmade chemicals and toxins.

WHAT

1-3 procedures annually

WHY

Manmade chemicals such as PFASs, microplastics, glyphosate and BPA  may accumulate in our bodies and are associated with various health issues. Our protocol effectively removes these chemicals from the blood, offering a solution to the buildup of harmful substances in our organs.

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WELLNESS PROTOCOL

WHO

Patients looking to improve overall health and longevity.

WHAT

Monthly for 3 months, followed by quarterly procedures.

WHY

Chronic inflammation, or ‘inflammaging’, is linked to various aging-related conditions. Our protocol offers a way to remove inflammatory molecules from the blood, potentially reducing biological age and improving overall health.

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Wellness Treatment

For patients looking to improve their overall health and longevity

Rationale:

‘Inflammaging’ is the natural increase in chronic inflammation that accompanies ageing. It contributes to all of the most common ageing-associated conditions, including neurodegeneration, cardiovascular disease, cancer and diabetes22. Monthly treatment with a similar treatment, TPE, has been shown to reduce biological age23.
Prior to the Marker Treatment, there has been no effective way to safely remove a broad range of inflammation from our blood.

Treatment regime:

Quarterly or annual sessions. This protocol is based on existing protocols with TPE
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LONG COVID/ LYME PROTOCOL

WHO

Patients with long COVID-19 or post-treatment Lyme disease.

WHAT

2 weekly procedures, followed by monthly sessions as needed.

WHY

Increased inflammation can be a key feature in conditions like long COVID and PTLDS. Our protocol targets a reduction in inflammation and improves patient-reported symptoms and quality of life.

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Long-Term Post-COVID/LymeTreatment

For patients with post-acute sequelae of COVID-19 (PASC, also known as long COVID), post-treatment Lyme disease syndrome (PTLDS).

Rationale:

PASC and PTLDS are also associated with increased levels of inflammatory markers, and inflammation is thought to be a key contributor to the pathology of these conditions24,25. In our own experience in patients with PTLDS, one or two treatments can be enough to improve patient-reported symptoms and quality of life.

Treatment regime:

~2 weekly treatments, followed by monthly sessions as necessary to reduce symptoms (PASC, PTLDS). These protocols are based on published data on TPE, as well as our own experience with PTLDS
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GLP-1 AGONIST PROTOCOL

WHO

Patients taking GLP-1 agonists.

WHAT

1 procedure every 2-4 weeks during weight loss, then maintenance procedures.

WHY

Rapid weight loss results in remobilization of stored poisons and toxins released from fat. Removing the remobilized toxins helps prevent further toxicity. Our protocol offers a solution to address this issue.

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GLP-1 Agonist Co-treatment

For patients taking GLP-1 agonists, including semaglutide (Ozempic, Wegovy, Rybelsus), or liraglutide (Victoza, Saxenda)

Rationale:

Removes forever chemicals and endocrine disruptors during rapid weight loss. Many toxic chemicals, including to so-called persistent organic pollutants (POPs), are stored in fat26. When fat is rapidly burned these chemicals are released into the bloodstream and circulated to the organs27. Removing these toxins, which have accumulated in your body over a lifetime, is essential during rapid weight loss for two reasons. Firstly, these toxins can accumulate in other organs (such as the liver) following rapid weight loss, where they may cause organ damage27. Secondly, removing these chemicals may help patients keep the weight off once they discontinue GLP-1 agonist treatment: POP levels in visceral fat are associated with metabolic syndrome27, and may be associated with impaired glucose homeostasis and following weight loss28 as seen in previous studies.
As the total body burden of POPs increases with weight, those with a higher starting weight will likely need more maintenance treatment.

Treatment regime:

1 treatment every 2-4 weeks during times of rapid weight loss, then 1 treatment every 3-6 months for maintenance
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NEURODEGENERATIVE PROTOCOL

WHO

Patients with early-stage neurodegenerative diseases.

WHAT

6 procedures over the first 3 months, then 1 procedure per month.

WHY

Neuroinflammation is a common feature in neurodegenerative diseases. Our protocol targets a reduction in neuroinflammation and can potentially slow cognitive decline in conditions like Alzheimer’s and Parkinson’s.

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Neurodegenerative Disease Treatment

For patients with early stage (mild or moderate) neurodegenerative diseases, including Alzheimer’s Disease (AD) or Parkinson’s Disease (PD)

Rationale:

Chronic inflammation is a key feature of multiple neurodegenerative diseases, including AD1 and PD2, as inflammation damages neurons and other cells in the brain. Our Marker Treatment helps remove this inflammation.

Treatment regime:

6 treatments over the first 3 months (one every 2 weeks), then 1 treatment per month thereafter. Our proposed protocol is based on established protocols using therapeutic plasma exchange (TPE) for the treatment of AD3.
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IMMUNE MEDIATED INFLAMMATORY DISEASE PROTOCOL

WHO

Patients with immune related inflammatory disorders.

WHAT

Procedure during flares, then maintenance procedures as needed.

WHY

Controlling inflammation is crucial. Our protocol focuses on reducing inflammatory cytokines and removing potential nephrotoxins to help manage autoimmune conditions more effectively.

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Immune-Mediated Inflammatory Disease Treatment

For patients with immune-mediated inflammatory disorders (IMIDs), including pyoderma gangrenosum, rheumatoid arthritis and systemic lupus erythematosus (SLE)

Rationale:

Controlling inflammation is essential to managing multiple IMIDs. Our Marker Treatment reduces inflammatory cytokines, which may extend the period between autoimmune episodes or reduces severity of existing episodes.
The Marker Treatment also removes free kappa and lambda light chains; these potential nephrotoxins are elevated in individuals with SLE and levels correlate with disease severity4. We hypothesize that stresses in the kidney caused by light chains cause cellular damage in vulnerable cells and may promote the conversion of SLE to lupus nephritis (LN)5. Removing these light chains may further delay disease progression as well as provide some renal support.

Treatment regime:

Daily or weekly treatments during flares, then maintenance treatments every 1 to 3 months. Our proposed protocol is based on our experience in pyoderma gangrenosum and renal support in compromised patients.
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FERTILITY PROTOCOL

WHO

Couples trying to conceive.

WHAT

1-2 procedures for both partners before conception.

1-2 procedures before assisted reproduction procedures.

WHY

Forever chemicals and inflammation can negatively impact fertility in both men and women. Our protocol targets removal of harmful toxins and inflammatory cytokines to improve fertility outcomes and create a healthier environment for conception and pregnancy. first step towards building your family and book a treatment today.

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Fertility Treatment

For couples trying to conceive

Rationale:

Per- and polyfluoroalkyl substances (PFASs) can disrupt hormone levels, particularly estrogen and progesterone, which are critical for ovulation, conception, and maintaining pregnancy6. PFAS levels are linked to reduced fertility in both men and women, as they can impair ovarian function, lower sperm quality, and affect embryo implantation7.
Other environmental toxins, glyphosate and microplastics, accumulate in the testes; in a recent study, both glyphosate and microplastics were found at various levels in every human testicle analysed8. Microplastics dose-dependently reduce sperm quality9.
Inflammation In women reduces fertility as it impairs egg quality and implantation, and contributes to conditions like polycystic ovary syndrome (PCOS) and endometriosis10, which reduce fertility. In men, inflammation can lower sperm quality and count, affecting overall reproductive health.
The Marker Treatment removes forever chemicals including PFASs, microplastics, and inflammation. This three-pronged system reset should improve fertility in both men and women, thereby creating a healthy environment for conception and pregnancy.

Treatment regime:

Regime 1: 1 to 2 treatments for both partners before conception, potentially repeated after 3 months if still trying to conceive. Our proposed protocol is based on our bench testing, in which we remove 35-99% of these chemicals per treatment.
Regime 2: 1 treatment before collection of sperm and/or eggs for assisted eproduction, including in vitro fertilization.
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